- Abrams: Siphon Life, Shoulder Charge (T3 bonus weapon damage)
- Apollo: Disengaging Sigil (T1 fire rate and bullet speed), Riposte (only the buffs are removed; otherwise blocks the Cursed Relic itself), Flawless Advance (T2 bullet resistance), Itani Lo Sahn (only interruptible during the cast)
- Bebop: Exploding Uppercut (T2 buffs), Sticky Bomb (only when cast on self or an ally; the bomb is dropped on the ground), Hyper Beam
- Billy: Bashdown, Rising Ram (T1 weapon damage), Blasted
- Calico: Leaping Slash, Ava
- Celeste: Dazzling Trick, Radiant Daggers, Shining Wonder (only interruptible during the cast)
- Dynamo: Rejuvenating Aurora, Singularity
- Graves: Borrowed Decree (only interruptible during the cast)
- Grey Talon: Charged Shot, Rain of Arrows (makes him fall out of the sky), Guided Owl (owl blows up wherever it was)
- Haze: Smoke Bomb, Bullet Dance
- Holliday: Bounce Pad (stomp damage and air control)
- Infernus: Flame Dash
- Ivy: Kudzu Connection (even when T3), Air Drop (stops the flight; bomb/ally stil deals damage)
- Kelvin: Ice Path
- Lady Geist: Life Drain, Soul Exchange (T3 buffs)
- Lash: Grapple (T2/T3 buffs), Death Slam
- McGinnis: Medicinal Specter (T1 spirit resist), Heavy Barrage
- Mina: Sanguine Retreat (T1 fire rate), Love Bites (T3 fire rate), Nox Nostra
- Mirage: Dust Devil (bullet evasion), Traveler (T1/T2 buffs)
- Mo & Krill: Burrow (only interruptible during the cast), Combo
- Paige: Plot Armor, Rallying Charge
- Paradox: Kinetic Carbine, Paradoxical Swap (T1 barrier)
- Pocket: Barrage (pocket extra damage), Flying Cloak (T2 weapon damage)
- Rem: Tag Along (T3 Spirit Power), Lil Helpers (removed from allies if the ally is cursed; no effect if Rem is cursed), Naptime
- Seven: Power Surge, Storm Cloud
- Shiv: Slice and Dice
- Silver: Slam Fire, Boot Kick (only interruptible during the cast)
- Silver (Transformed): Mauling Leap
- Sinclair: Spectral Assistant (T3 fire rate)
- The Doorman: Doorway (T1 Barrier), Hotel Guest (only interruptible during the cast)
- Venator: Gutshot (T3 bless)
- Victor: Jumpstart, Aura of Suffering
- Vindicta: Flight
- Viscous: The Cube, Goo Ball
- Vyper: Slither (T3 barrier)
- Warden: Willpower, Last Stand
- Wraith: Project Mind, Full Auto, Telekinesis (interrupts the cast/targeting; does not prevent the damage/throw)
- Yamato: Power Slash, Flying Slash (still flies to the target but deals no damage), Crimson Slash (T1 melee damage)