Toxic Bullets
Cost  3,200
Tier 3
Passive
Your bullets build up a Bleed on enemies, causing them to lose a percentage of their Max Health over time. Also applies Healing Reduction on the bleeding target.
  1.9  x0.005%/sec
Bleed Damage
  -35%
Healing Reduction
Conditional
4s Duration
Internal name: upgrade_toxic_bullets
Sounds

Toxic Bullets
Cost  3,200
Tier 3
Enhanced 
Passive
Your bullets build up a Bleed on enemies, causing them to lose a percentage of their Max Health over time. Also applies Healing Reduction on the bleeding target.
  -65%
Healing Reduction
Conditional
4s Duration
Internal name: upgrade_toxic_bullets
Sounds

Toxic Bullets is a Tier 3 Weapon Item that can be purchased from the Shop for Souls3,200.

Notes

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  • Bleed damage can kill.
  • The bleed effect is indicated by puddles of blood dropping from the player.
  • Bleed damage applies or "ticks" every half-second, dealing slightly over 1.2% max health spirit damage per tick. This means that, by default, bleed applies damage six times every time it is successfully built up for 7.5% max health spirit damage.
  • Bleed Damage is considered Spirit Damage and is reduced by Spirit Resist.
  • The duration of the bleed is affected by the Ability Duration stat, such as from Superior Duration. The extra damage is applied proportionally. For instance, since Superior Duration adds .84 seconds to the bleed effect, the bleed will deal 2.1% extra spirit damage for a total of 9.6% max health spirit damage.
  • Headshots do not affect the Build-Up per shot.
  • Does not build-up with melee hits, unlike other weapon build-up items (  Slowing Bullets etc.)
  • Bleed does not build on any structures, such as Guardians and Walkers. Mid-boss is also immune to bleed.
  • Bleed does build on Troopers and Denizens, but deals 50% damage.
  • The healing reduction only applies while the target is bleeding.
  • The healing reduction stacks with other sources of healing reduction. For instance,   Healbane and Toxic Bullets will apply a healing reduction effect of 55%.
  • The buildup per shot is also affected by weapon falloff, requiring more shots for the bleed to occur at further distances. Once applied, the bleed damage itself is unaffected by distance.
  • For heroes with spreadshot weapons (  Abrams,   Calico,   Yamato, etc.), the listed bleed buildup applies on a shot where every pellet hits its target. The buildup is divided evenly between each pellet and missing one pellet will proportionally decrease buildup.
  • For characters with burst-fire weapons (  Lash,   Seven, etc.), the listed bleed buildup applies for each bullet rather than each burst. Landing a full burst as Lash, for instance, will build 45.9% of bleed on a target.
  • For characters with splash damage alternate fire weapons (  Viscous and   Yamato), the listed bleed buildup applies in full regardless of whether a target was hit directly or indirectly with a shot.
  •   Shiv's alt-fire builds bleed identically to his primary fire.

Buildup Per Shot

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The item has a different buildup per shot depending on which hero purchased the item. The bleed only triggers on an enemy once the buildup reaches 100%, and the buildup decays back to 0 over time if the enemy has not been shot recently. Subsequent shots on a bleeding enemy (bullets or melee) refreshes the duration of the bleed.

Buildup Per Bullet: Toxic Bullets
Hero% per bulletBullets/ShotShots to Proc
(all bullets hit)
  Abrams3.494
  Apollo21.55
  Bebop6.117
  Billy6.117
  Calico1.598
  Celeste28.74
  The Doorman28.74
  Drifter8.035
  Dynamo16.27
  Graves7.214
  Grey Talon29.34
  Haze7.414
  Holliday25.14
  Infernus7.414
  Ivy5.319
  Kelvin16.27
  Lady Geist25.14
  Lash11.49
  McGinnis6.117
  Mina15.77
  Mirage21.05
  Mo & Krill3.149
  Paige22.35
  Paradox9.111
  Pocket3.874
  Rem16.17
  Seven11.49
  Shiv4.664
  Silver5.173
  Silver (Transformed)37.03
  Sinclair21.05
  Venator8.712
  Victor11.49
  Vindicta14.77
  Viscous13.68
  Vyper5.120
  Warden16.27
  Wraith6.715
  Yamato4.655

Affected healing

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Following abilities and items get their healing reduced by Toxic Bullets.

Heroes

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This is a dynamic list "heal". Edit contents · Edit notes.
Hero Ability
  Abrams   Siphon Life
  Infernal Resilience
  Apollo   Flawless Advance
  Bebop   Exploding Uppercut
  Calico   Leaping Slash
  Return to Shadows
  Celeste   Light Eater
  Drifter   Bloodscent
  Dynamo   Rejuvenating Aurora
  Grey Talon   Rain of Arrows
  Infernus   Napalm
  Concussive Combustion
  Ivy   Kudzu Connection
  Stone Form
  Kelvin   Frost Grenade
  Frozen Shelter
  Lady Geist   Life Drain
  Soul Exchange
  Lash   Flog
  McGinnis   Medicinal Specter
  Mina   Rake
  Mo & Krill   Scorn
  Combo
  Paige   Rallying Charge
  Rem   Tag Along
  Lil Helpers
  Silver   Lycan Curse
  Silver (Transformed)   Go For The Throat
  Victor   Pain Battery
  Jumpstart
  Viscous   The Cube
  Puddle Punch
  Warden   Last Stand
  Wraith   Card Trick
  Yamato   Crimson Slash
  Shadow Transformation

Items

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Direct Heal items

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List of items
Name   Cost Category Healing amount
  Restorative Shot 800   Weapon 50 Healing From Heroes
20 Healing From NPCs
  Headhunter 3,200   Weapon 4%  x0.06 Heal Per Headshot
  Healing Rite 800   Vitality 300  x1.1 Total HP Regen
  Melee Lifesteal 800   Vitality 100 Heal on Melee Hit (30% on NPCs)
  Rebuttal 800   Vitality 100% Of the incoming melee damage is healed on successful parry
  Healbane 1,600   Vitality 275 Heal On Hero Kill
  Restorative Locket 1,600   Vitality 16  x0.5 Heal Per Stack
  Counterspell 3,200   Vitality 150 Heal on successful spell parry
  Dispel Magic 3,200   Vitality 250 Heal on successful debuff cleanse
  Fortitude 3200   Vitality Heal 2% of max HP each second while out of combat
  Healing Nova 3,200   Vitality 325  x6 Total HP Regen
  Lifestrike 3,200   Vitality 100  x1.5 Heal on Melee Hit, plus 30%  x0.5 Lifesteal (40% on NPCs)
  Rescue Beam 3,200   Vitality 20% Heal Amount
  Veil Walker 3,200   Vitality 85  x8 Heal When traversing through a Veil
  Mystic Regeneration 800   Spirit 4 Bonus HP regeneration on spirit damage dealt to enemy heroes
  Radiant Regeneration 3,200   Spirit 4  x0.04 HP/s Regeneration on spirit damage dealt to enemy heroes
65  x2 Heal on Ability Cast

Bullet Lifesteal items

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This is a dynamic list "bullet lifesteal". Edit contents.
Name CostCategoryStat change
  Active Reload1,600  Weapon+16% Bullet lifesteal
  Frenzy6,400  Weapon+10% Bullet lifesteal
  Bullet Lifesteal1,600  Vitality+13% Bullet lifesteal
  Fury Trance3,200  Vitality+14% Bullet lifesteal
  Leech6,400  Vitality+25% Bullet lifesteal
  Vampiric Burst6,400  Vitality+13% Bullet lifesteal
+70% Bullet lifesteal

Spirit Lifesteal items

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This is a dynamic list "spirit lifesteal". Edit contents.
Name CostCategoryStat change
  Spirit Shredder Bullets1,600  Weapon+10% Spirit lifesteal
  Spirit Rend3,200  Weapon+10% Spirit lifesteal
  Spiritual Overflow6,400  Weapon+13% Spirit lifesteal
  Spirit Lifesteal1,600  Vitality+13% Spirit lifesteal
  Infuser6,400  Vitality+70% Spirit lifesteal
  Leech6,400  Vitality+25% Spirit lifesteal
  Mystic Reverb6,400  Spirit+8% Spirit lifesteal

Update history

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View the full update history: Toxic Bullets/Update history

Update Changes

June 30, 2026

  • Bleed damage increased from 1.7% to 1.9%.

May 22, 2026

  • No longer builds up from melee attacks.

April 10, 2026

  • Buildup is now 10% slower.
  • Bleed reduced from 2% to 1.7%.
  • Anti Heal increased from -30% to -35%.
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Weapon
Vitality
Spirit